Publications

Research Articles

  1. A. R. Nödling, K. Świderek, R. Castillo, J. W. Hall, A. Angelastro, L. C. Morrill, Y. Jin, Y.-H. Tsai, V. Moliner, L. Y. P. Luk, Reactivity and selectivity of iminium organocatalysis improved by a protein host. Angew. Chem. Int. Ed. 2018, 57, in press.
  2. T. Suzuki, M. Asami, S. G. Patel, L. Y. P. Luk, Y.-H. Tsai, A. C. F. Perry, Switchable genome editing via genetic code expansion. Sci. Rep. 2018, 8, 10051. News in The Conversation and Biotechnology and Biological Sciences Research Council (BBSRC). Press releases from Cardiff University and University of Bath.
  3. K. Świderek, A. R. Nödling, Y.-H. Tsai, L. Y. P. Luk, V. Moliner, Reaction mechanism of organocatalytic Michael addition of nitromethane to cinnamaldehyde: a case study on catalyst regeneration and solvent effects. J. Phys. Chem. A 2018, 122, 451.
  4. J.-H. Liao, C.-H. Tsai, S. G. Patel, J.-T. Yang, I-F. Tu, M. Lo Cicero, M. Lipka-Lloyd, W.-L. Wu, W.-J. Shen, M.-R. Ho, C.-C. Chou, G. R. Sharma, H. Okanishi, L. Y. P. Luk, Y.-H. Tsai, S.-H. Wu, Acetylome of Acinetobacter baumannii SK17 reveals a highly-conserved modification of histone-like protein HU. Front. Mol. Biosci. 2017, 4, 77. News in The Conversation.
  5. S.-J. Lai, I-F. Tu, W.-L. Wu, J.-T. Yang, L. Y. P. Luk, M.-C. Lai, Y.-H. Tsai, S.-H. Wu, Site-specific His/Asp phosphoproteomic analysis of prokaryotes reveals putative targets for drug resistance. BMC Microbiol. 2017, 17, 123.
  6. Y.-H. Tsai, S. Essig, J. R. James, K. Lang, J. W. Chin, Selective, rapid and optically switchable regulation of protein function in live mammalian cells. Nat. Chem. 2015, 7, 554. News in C&EN.
  7. S. Götze, A. Reinhardt, A. Geißner, N. Azzouz, Y.-H. Tsai, R. Kurucz, D. Varon Silva, P. H. Seeberger, Investigation of the protective properties of glycosylphosphatidylinositol-based vaccine candidates in a Toxoplasma gondii mouse challenge model. Glycobiology 2015, 25, 984.
  8. S. Götze, N. Azzouz, Y.-H. Tsai, U. Groß, A. Reinhardt, C. Anish, P. H. Seeberger, D. Varon Silva, Diagnosis of toxoplasmosis using a dynthetic glycosylphosphatidylinositol glycan. Angew. Chem. Int. Ed. 2014, 53, 13701.
  9. Y.-H. Tsai, S. Götze, I. Vilotijevic, M. Grube, D. Varon Silva, P. H. Seeberger, A general and convergent synthesis of diverse glycosylphosphatidylinositol glycolipids. Chem. Sci. 2013, 4, 468.
  10. Y.-H. Tsai, S. Götze, N. Azzouz, H. S. Hahm, P. H. Seeberger, D. Varon Silva, A general method for synthesis of GPI anchors illustrated by the total synthesis of the low molecular weight antigen from Toxoplasma gondii. Angew. Chem. Int. Ed. 2011, 50, 9961.
  11. M.-L. Hecht, Y.-H. Tsai, X. Liu, C. Wolfrum, P. H. Seeberger, Synthetic inositol phosphoglycans related to GPI lack insulin-mimetic activity. ACS Chem. Biol. 2010, 5, 1075.
  12. M. Oberli, M. Tamborrini, Y.-H. Tsai, D. B. Werz, T. Horlacher, A. Adibekian, D. Gauss, H. M. Möller, G. Pluschke, P. H. Seeberger, Molecular analysis of carbohydrate-antibody interactions: case study using a Bacillus anthracis tetrasaccharide. J. Am. Chem. Soc. 2010, 132, 10239.
  13. R. Kikkeri, X. Liu, A. Adibekian, Y.-H. Tsai, P. H. Seeberger, Facile synthesis of size dependent Ru(II)–carbohydrate dendrimers via click chemistry. Chem. Commun. 2010, 13, 2197.
  14. Y.-L. Yang, F.-L. Yang, Z.-Y. Huang, Y.-H. Tsai, W. Zou, S.-H. Wu, Structural variation of glycolipids from Meiothermus taiwanensis ATCC BAA-400 under different growth temperatures. Org. Biomol. Chem. 2010, 8, 4252.
  15. C.-T. Ren, Y.-H. Tsai, Y.-L. Yang, W. Zou, S.-H. Wu, Synthesis of a tetrasaccharide glycosyl glycerol. Precursor to glycolipids of Meiothermus taiwanensis ATCC BAA-400. J. Org. Chem. 2007, 72, 5427.

Reviews

  1. Y.-H. Tsai, X. Liu, P. H. Seeberger, Chemical biology of glycosylphosphatidylinositol anchors. Angew. Chem. Int. Ed. 2012, 51, 11438.
  2. Y.-H. Tsai, M. Grube, P. H. Seeberger, D. Varon Silva, Glycosylphosphatidylinositols of protozoan parasites. Trends Glycosci. Glycotechnol. 2012, 24, 231.

Patent Applications

  1. N. Azzouz, S. Götze, P. H. Seeberger, D. Varon Silva, Y.-H. Tsai, Synthesis of diverse glycosylphosphatidylinositol glycans from Toxoplasma gondii and their application as vaccines and diagnostics. European Patent Application EP2690104 A1, filed 24/07/2012; European Patent Application EP2890703 A1, filed 23/07/2013; US Patent Application US20150203523 A1, filed 23/07/2013; World Patent Application WO2014016317 A1, filed 23/07/2013.
  2. N. Azzouz, S. Götze, P. H. Seeberger, D. Varon Silva, Y.-H. Tsai, Synthesis of diverse glycosylphosphatidylinositol glycans and glycolipids from Toxoplasma gondii and their application as diagnostic markers and vaccines. European Patent Application EP2690438 A1, filed 24/07/2012.

 

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